Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

In this article, we demonstrated that a long non-coding RNA, _Meg3_, is required to establish the boundary between two genes that mark spinal motor neurons from different body segments. To suppress the expression of caudal genes from expressing in rostral segments, _Meg3_ forms a complex with PRC2 to suppress them, the catalytic complex that marks histone with repressive modificication H3K27me3.