ALS

Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration

Amyotrophic lateral sclerosis is a neurodegenerative disease that causes progressive paralysis that is lethal and incurable to date. In this article, we discovered a developmentally critical microRNA cluster, _mir-17~92_, plays a role in the vulnerability of spinal motor neurons and supplementing this microRNA cluster can prolong the life expectancy in a mouse disease model.