Blog Posts

Compiling with libxml in MacOS Catalina

The problem When compiling Emacs 28.05, make bootstrap failed with fatal error: 'libxml/tree.h' file not found while autogen.sh and configure were successfully executed. Troubleshooting The error message pointed out the culprit, libxml.
Compiling with libxml in MacOS Catalina

Dependency issue: In Conda, with SCENIC

I’ve been working with pySCENIC in the recent couples of months. It’s a tool that is meant to uncover gene sets that are controlled by transcription factors and suggests the underlying logic of how genes are regulated.

psutil, python, and icc

I used to dislike dependency management because there are so many things that require root or are mysteriously incompatible with each other. However, I recently came to realize that the existence of dependency itself is a delicate and elegant system despite being messy at times.

Be a deTeXtive

Self-handicapping can be quite productive on those non-urgent things. Recently, I noticed a LaTeX template, Awesome CV, so I was thinking trying it to replace Modern CV, which has accompanied me for around three years.

Strangled by factors

I am exaggerating, but sometimes stringsAsFactors is almost this deadly. I work with genomic data, and a common quest in my job is to identify interesting features (in most cases, genes) from a pool of 25,000+.
Strangled by factors

Recent Publications

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Gene Regulatory Networks During the Development of the Drosophila Visual System

The Drosophila visual system integrates input from 800 ommatidia and extracts different features in stereotypically connected optic …
Gene Regulatory Networks During the Development of the Drosophila Visual System

Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration

Amyotrophic lateral sclerosis is a neurodegenerative disease that causes progressive paralysis that is lethal and incurable to date. In this article, we discovered a developmentally critical microRNA cluster, mir-17~92, plays a role in the vulnerability of spinal motor neurons and supplementing this microRNA cluster can prolong the life expectancy in a mouse disease model.
Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration

Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

In this article, we demonstrated that a long non-coding RNA, Meg3, is required to establish the boundary between two genes that mark spinal motor neurons from different body segments. To suppress the expression of caudal genes from expressing in rostral segments, Meg3 forms a complex with PRC2 to suppress them, the catalytic complex that marks histone with repressive modificication H3K27me3.
Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

PhD Student

New York University

Yen-Chung Chen is a PhD student in the Desplan lab at New York University. My research interests include how neuronal fate is specified into different subtypes and how cell fate leads to the establishment and maintenance of distinct features like precise selection of synaptic partners, the use of neurotransmitters, and unique firing patterns.

Interests

  • Developmental biology
  • Neurobiology
  • Bioinformatics